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JAK1-IN-14

CAT: 0804-HY-161139Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161139Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK1-IN-14 (Compound 12a) is a potent and selective JAK1 inhibitor. JAK1-IN-14 inhibits JAK1 and JAK2 with an IC50 value of 12.6 nM and 135 nM. JAK1-IN-14 suppresses hepatic fibrosis levels and can be used for the research of liver fibrosis and inflammatory diseases[1].
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak1-in-14.html
Solubility
10 mM in DMSO
Smiles
CN(C1CCN(CC(N2CCC(C)CC2)=O)CC1)C3=C4C(NC=C4)=NC=N3
Molecular Formula
C20H30N6O
Molecular Weight
370.49
References & Citations
[1]Zhang J, et al. Structure-guided design of potent JAK1-selective inhibitors based on 4-amino-7H-pyrrolo[2,3-d]pyrimidine with anti-inflammatory efficacy. Arch Pharm (Weinheim) . 2024 Jan 7:e2300591.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2

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