EGFR-IN-96

CAT: 0804-HY-161067Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161067Size:1 Each
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Description
EGFR-IN-96 (compound 7a) is a thieno[2,3-d]pyrimidine EGFR inhibitor that can induce apoptosis. EGFR-IN-96 arrests the growth of HepG2 cells in the S phase and G2/M phase, and inhibits the growth of cancer cells bearing EGFR wild-type and EGFRT790M[1].
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-96.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1)NNC2=NC=NC3=C2C(CCC(C)C4)=C4S3
Molecular Formula
C18H19N5OS
Molecular Weight
353.44
References & Citations
[1]Sobh EA, et al. Discovery of new thieno[2,3-d]pyrimidines as EGFR tyrosine kinase inhibitors for cancer treatment. Future Med Chem. 2023 Jul;15 (13) :1167-1184.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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