PIM-IN-2

PIM-IN-2

• CAS Number: 1006699-45-1
• UNSPSC Description: PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC50 = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors[1].
• Target Antigen: Pim
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pim-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: OC(/C=C/C1=CC=CC(C2=NC(NCC3CCNCC3)=CN=C2)=C1)=O
• Molecular Weight: 338.40
• References & Citations: [1]Qian K, et al. Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode [J]. Journal of medicinal chemistry, 2009, 52(7): 1814-1827.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported