PIM-IN-2

• UNSPSC Description:

  PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC50 = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors[1].

• Target Antigen:

  Pim

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pim-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(/C=C/C1=CC=CC(C2=NC(NCC3CCNCC3)=CN=C2)=C1)=O

• Molecular Weight:

  338.40

• References & Citations:

  [1]Qian K, et al. Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode [J]. Journal of medicinal chemistry, 2009, 52(7): 1814-1827.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1006699-45-1