BX-2819

• Description:

  BX-2819 is a Hsp90 inhibitor with an IC50 value of 41 nM. BX-2819 inhibits the proliferation of cancer cells. BX-2819 can significantly inhibit the growth of NCI-N87 and HT-29 tumors in nude mice[1].

• UNSPSC:

  12352005

• Target:

  HSP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bx-2819.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCOC(NCC1=CC=C(C=C1)N2C(NN=C2C3=C(C=C(C(C(C)C)=C3)O)O)=S)=O

• Molecular Formula:

  C21H24N4O4S

• Molecular Weight:

  428.50

• References & Citations:

  [1]Feldman RI, et al. Potent triazolothione inhibitor of heat-shock protein-90. Chem Biol Drug Des. 2009 Jul;74 (1) :43-50.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HSP70; HSP90

• CAS Number:

  [1184181-50-7]