BX-2819

• Description :

  BX-2819 is a Hsp90 inhibitor with an IC50 value of 41 nM. BX-2819 inhibits the proliferation of cancer cells. BX-2819 can significantly inhibit the growth of NCI-N87 and HT-29 tumors in nude mice[1].

• UNSPSC :

  12352005

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bx-2819.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCOC(NCC1=CC=C(C=C1)N2C(NN=C2C3=C(C=C(C(C(C)C)=C3)O)O)=S)=O

• Molecular Formula :

  C21H24N4O4S

• Molecular Weight :

  428.50

• References & Citations :

  [1]Feldman RI, et al. Potent triazolothione inhibitor of heat-shock protein-90. Chem Biol Drug Des. 2009 Jul;74 (1) :43-50.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP70; HSP90

• CAS Number :

  [1184181-50-7]