BX-912

• Description :

  BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC50=26 nM) . BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Apoptosis; PDK-1

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/BX-912.html

• Purity :

  99.06

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  BrC1=C(NCCC2=CNC=N2)N=C(NC3=CC(NC(N4CCCC4)=O)=CC=C3)N=C1

• Molecular Formula :

  C20H23BrN8O

• Molecular Weight :

  471.35

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Feldman RI, et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280 (20) :19867-74.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [702674-56-4]