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RIOK2-IN-1

CAT: 0804-HY-156792Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156792Size:1 Each
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Description
RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 , an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression[1].
CAS Number
1088216-72-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Ser/Thr Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/riok2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1=CC2=C(C=CC=C2)C=C1)NC3=NC=CC(C)=C3
Molecular Formula
C18H16N2O
Molecular Weight
276.33
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Ouyang Y, et al. Discovery of 8- (6-Methoxypyridin-3-yl) -1- (4- (piperazin-1-yl) -3- (trifluoromethyl) phenyl) -1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65 (11) :7833-7842.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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