D-4-77

• Description :

  D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 0.95 μM. D-4-77 has antiviral active with an EC50 value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response[1].

• UNSPSC :

  12352005

• Target :

  SARS-CoV; Virus Protease

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/d-4-77.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=CC=C(C[C@@H](C(OC)=O)NC([C@@H](NC([C@@H](NC(CBr)=O)C)=O)[C@@H](C)CC)=O)C(C)=C1

• Molecular Formula :

  C23H34BrN3O5

• Molecular Weight :

  512.44

• References & Citations :

  [1]Liu M, et, al. The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors. Angew Chem Int Ed Engl. 2023 Aug 23:e202309657.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported