D-4-77

• UNSPSC Description:

  D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 0.95 μM. D-4-77 has antiviral active with an EC50 value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response[1].

• Target Antigen:

  SARS-CoV; Virus Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/d-4-77.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C(C[C@@H](C(OC)=O)NC([C@@H](NC([C@@H](NC(CBr)=O)C)=O)[C@@H](C)CC)=O)C(C)=C1

• Molecular Weight:

  512.44

• References & Citations:

  [1]Liu M, et, al. The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors. Angew Chem Int Ed Engl. 2023 Aug 23:e202309657.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported