D-4-77

CAT: 0804-HY-156734Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-156734Size:1 Each

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Description

D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 0.95 μM. D-4-77 has antiviral active with an EC50 value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response[1].

UNSPSC

12352005

Target

SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/d-4-77.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(C[C@@H](C(OC)=O)NC([C@@H](NC([C@@H](NC(CBr)=O)C)=O)[C@@H](C)CC)=O)C(C)=C1

Molecular Formula

C23H34BrN3O5

Molecular Weight

512.44

References & Citations

[1]Liu M, et, al. The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors. Angew Chem Int Ed Engl. 2023 Aug 23:e202309657.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Alternative Products

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GTR19230174-01	D-4-77
MBS131177-01	D-77
sc-130431	MSK1 (D-77)
AR-B07336-01	3,3',4,4'-Tetrabromobiphenyl (PBB 77)
A3132-5.1	A 77-01
BA3742-5	DEG-77
B4881-5	UMI-77
T24464-01	ZXX2-77
T35096	W 77
ABC-TC1319	SHP-77

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