RegisterLogin

D359-0396

CAT: 0804-HY-156374-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-156374-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice[1].
CAS Number
[1031977-31-7]
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/d359-0396.html
Purity
99.98
Solubility
10 mM in DMSO
Smiles
O=C1C2=CN3C4=C(NC(C3=C2N(C)C(N1C)=O)C5=CC=C(C(C)C)C=C5)C=CC=C4
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
References & Citations
[1]Li Z, et al. Identification of D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome. Neurochem Int. 2023 Oct;169:105565.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-50722-01NNC 55-0396
HY-50722A-01(Rac) -NNC 55-0396
HY-118904VL-0395
HY-162472-01XRD-0394
HY-146894SDSPC-d35
HY-18944-01FIT-039
HY-B2219S4-01Stearic acid-d35
HY-W133986S1-01Stearate-d35 (potassium)
HY-W099570S-01Stearate-d35 (sodium)
HY-W013809S-01Ethyl stearate-d35

Alternative Products

CatalogName
T82621-01D359-0396
MBS3840909-01NNC 55-0396
A15188-100NNC 55-0396 100mg
A15188-1NNC 55-0396 1mg
526807NNC 55-0396 HCl
A15188-5NNC 55-0396 5mg
256008NNC 55-0396 dihydrochloride
A15188-10NNC 55-0396 10mg
A15188-25NNC 55-0396 25mg
A15188-50NNC 55-0396 50mg

Popular Products