CYP51/PD-L1-IN-4

CYP51/PD-L1-IN-4

• UNSPSC Description: CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target (CYP51/PD-L1) inhibitor, with IC50 values of 0.17 and 0.021 μM, respectively. CYP51/PD-L1-IN-4 exhibits excellent antifungal and antidrug-resistant fungal activity in vitro. CYP51/PD-L1-IN-4 can be used for fungal infections research[1].
• Target Antigen: Cytochrome P450; PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/cyp51-pd-l1-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C2=CC=CC=C2)C=CC=C1COC3=CC=CC(CN[C@@](CN4N=CN=C4)(C(OC)=O)[H])=C3
• Molecular Weight: 456.54
• References & Citations: [1]Liu Y, et al. Construction and Evaluation of Novel Dual-function Antifungal Inhibitors and Covalent Organic Framework Carriers Based on the Infection Microenvironment. J Med Chem. 2023 Oct 12;66(19):13838-13857.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported