α-Glucosidase-IN-32

α-Glucosidase-IN-32

• UNSPSC Description: α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC50 value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research[1].
• Target Antigen: Glycosidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/α-glucosidase-in-32.html
• Solubility: 10 mM in DMSO
• Smiles: C1(C2=NC(C3=NN=C(SCC4=CC=CC=C4C5=CC=CC=C5)O3)=CC6=C2NC7=CC=CC=C67)=CC=CC=C1
• Molecular Weight: 510.61
• References & Citations: [1]Xiao D, et al. Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity. Eur J Med Chem. 2023 Sep 7;261:115795.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported