McMMAF (GMP)

• Description :

  McMMAF GMP is a GMP grade McMMAF (HY-15578) . McMMAF is a protective group (maleimidocaproyl) -conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC) . McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent[1][2].

• Product Name Alternative :

  Maleimidocaproyl monomethylauristatin F (GMP)

• UNSPSC :

  12352005

• Hazard Statement :

  H300-H310-H330

• Target :

  Drug-Linker Conjugates for ADC

• Type :

  GMP Small Molecules

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mcmmaf-gmp.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@@]([H])(N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)C)[C@@H](C)CC)=O)OC)N[C@H](C(O)=O)CC3=CC=CC=C3

• Molecular Formula :

  C49H76N6O11

• Molecular Weight :

  925.16

• Precautions :

  P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

• References & Citations :

  [1]Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69 (6) :2358-2364.|[2]Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  GMP Small Molecules

• Clinical Information :

  No Development Reported

• CAS Number :

  [863971-19-1]