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MTP

CAT: 0804-HY-155785Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155785Size:1 Each
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Description
MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma[1].
CAS Number
2377372-62-6
UNSPSC
12352005
Target
Apoptosis; Autophagy; JAK; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtp.html
Solubility
10 mM in DMSO
Smiles
C#CC(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F)CCC(NC)=O)=O
Molecular Formula
C29H23F3N4O2
Molecular Weight
516.51
References & Citations
[1]Weng JR, et al. A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. Chem Biol Interact. 2023 Aug 1;380:110538.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
JAK2

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