SIRT1/2/3-IN-1

SIRT1/2/3-IN-1

• CAS Number: 2413212-06-1
• UNSPSC Description: SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of SIRT1, SIRT2 and SIRT3 with IC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer[1].
• Target Antigen: Sirtuin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sirt1-2-3-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H](NC1=O)CCSC)NCCCCCOC2=CC=C(C=C2)C[C@@H]1NC([C@H](CCCCNC(C)=S)NC([C@@H]3CC4=CC=C(OCCCC(N[C@H](C(N3)=O)CC5=CN=CN5)=O)C=C4)=O)=O
• Molecular Weight: 934.18
• References & Citations: [1]Li R , et al. A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine[J]. Bioorganic & Medicinal Chemistry, 2020, 28(7):115356.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported