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IRAK4-IN-11

CAT: 0804-HY-146072Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146072Size:1 Each
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Description
IRAK4-IN-11 (compound 6) is a potent IRAK4 inhibitor with an IC50 of 0.008 µM. IRAK4-IN-11 shows cell pIRAK4 potencies with an IC50 of 0.19 µM[1].
CAS Number
3032742-74-5
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/irak4-in-11.html
Solubility
10 mM in DMSO
Smiles
CN1C=C(C=N1)NC2=NC3=C(C(NC4(CC4)C)=N2)C(N(C=C3)C)=O
Molecular Formula
C16H19N7O
Molecular Weight
325.37
References & Citations
[1]Cumming IA, et al. Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorg Med Chem. 2022 Jun 1;63:116729.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

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