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FY-21

CAT: 0804-HY-155526Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155526Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity[1].
CAS Number
[3049681-20-8]
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fy-21.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)[N+]([O-])=O)O.FC(C(O)=O)(F)F
Molecular Formula
C17H15F3N2O6
Molecular Weight
400.31
References & Citations
[1]Yang C, et al. Discovery of new tetrahydroisoquinolines as potent and selective LSD1 inhibitors for the treatment of MLL-rearranged leukemia. Eur J Med Chem. 2023 Sep 5;257:115516.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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