FY-21

• Description :

  FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity[1].

• UNSPSC :

  12352005

• Target :

  Histone Demethylase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fy-21.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)[N+]([O-])=O)O.FC(C(O)=O)(F)F

• Molecular Formula :

  C17H15F3N2O6

• Molecular Weight :

  400.31

• References & Citations :

  [1]Yang C, et al. Discovery of new tetrahydroisoquinolines as potent and selective LSD1 inhibitors for the treatment of MLL-rearranged leukemia. Eur J Med Chem. 2023 Sep 5;257:115516.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3049681-20-8]