GRL018-21

• Description :

  GRL018-21 is a potent and highly selective G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 value of 10 nM[1].

• UNSPSC :

  12352005

• Target :

  G Protein-coupled Receptor Kinase (GRK)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/grl018-21.html

• Purity :

  96.91

• Solubility :

  DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  FC1=CC=C([C@@H](C)NC(C2=CC=C(NC(/C3=C\C4=C(C)C(NC(C(C5=CC=CO5)=O)=O)=C(C)N4)=O)C3=C2)=O)C=C1

• Molecular Formula :

  C30H25FN4O5

• Molecular Weight :

  540.54

• References & Citations :

  [1]Chen Y, et al. Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes[J]. European Journal of Medicinal Chemistry, 2023: 115931.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported