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GRL018-21

CAT: 0804-HY-149720-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149720-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GRL018-21 is a potent and highly selective G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 value of 10 nM[1].
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/grl018-21.html
Purity
96.91
Solubility
DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=C([C@@H](C)NC(C2=CC=C(NC(/C3=C\C4=C(C)C(NC(C(C5=CC=CO5)=O)=O)=C(C)N4)=O)C3=C2)=O)C=C1
Molecular Formula
C30H25FN4O5
Molecular Weight
540.54
References & Citations
[1]Chen Y, et al. Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes[J]. European Journal of Medicinal Chemistry, 2023: 115931.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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