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INF200

CAT: 0804-HY-155517Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155517Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD) -induced metaflammation, and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles, and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP) . INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation[1].
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/inf200.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC=C1CC(O2)=NN(CC(OCC)=O)C2=O
Molecular Formula
C13H13ClN2O4
Molecular Weight
296.71
References & Citations
[1]Gastaldi S, et al. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation. Eur J Med Chem. 2023 Sep 5;257:115542.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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