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PqsR-IN-3

CAT: 0804-HY-155479Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155479Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PqsR-IN-3 (compound 16e) is a selective inhibitor of the pqs system (IC50=3.7 μM) and its associated virulence factor pyocyanin (IC50=2.7 μM). PqsR-IN-3 inhibits bacterial biofilm synthesis and is significantly cytotoxic against Pseudomonas aeruginosa. PqsR-IN-3 has synergistic effects with several antibiotics, such as Ciprofloxacin and Tobramycin (HY-B0441).
CAS Number
3033007-79-0
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pqsr-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C1C(O)=C(N(C(C)=C1)C)CNCC2=CN(N=N2)C3=CC=C(C=C3)OC4=CC=CC=C4
Molecular Formula
C23H23N5O3
Molecular Weight
417.46
References & Citations
[1]Miao ZY et al. 3-Hydroxypyridin-4 (1H) -one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa. J Med Chem. 2023 Nov 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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