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Estrogen receptor modulator 10

CAT: 0804-HY-155406Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155406Size:1 Each
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Description
Estrogen receptor modulator 10 (compound G-5b) is an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). Estrogen receptor modulator 10 is developed based on the Fulvestrant molecule and can rapidly degrade ER receptors through the proteasome pathway. Estrogen receptor modulator 10 can induce cell apoptosis and block cells in the G1/G0 phase and can be used in cancer research[1].
CAS Number
2991504-90-4
UNSPSC
12352005
Target
Bcl-2 Family; Caspase; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/estrogen-receptor-modulator-10.html
Solubility
10 mM in DMSO
Smiles
FC(C=C(NC1CN(CCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)C1)C=C2F)=C2[C@H]3N(CC(F)(F)CO)[C@H](C)CC4=C3NC5=CC=CC=C54
Molecular Formula
C32H37F9N4O3S
Molecular Weight
728.71
References & Citations
[1]Bingsi Wang, et al.A novel scaffold long-acting selective estrogen receptor antagonist and degrader with superior preclinical profile against ER+ breast cancer, European Journal of Medicinal Chemistry,2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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