12R-LOX-IN-1

12R-LOX-IN-1

• CAS Number: 857758-13-5
• UNSPSC Description: 12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: COVID-19-anti-virus
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/12r-lox-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: OC1=CC=C(N=C(C2=CC=CC=C2O)C=C3)C3=C1
• Molecular Weight: 237.25
• References & Citations: [1]Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported