12R-LOX-IN-2

CAT:

804-HY-155244-04

Size:

100 mg

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CAS Number: 3026677-37-9
UNSPSC Description: 12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases[1].
Target Antigen: DNA/RNA Synthesis; Lipoxygenase
Type: Reference compound
Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications: COVID-19-anti-virus
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/12r-lox-in-2.html
Solubility: DMSO : 125 mg/mL (ultrasonic)
Smiles: OC(C1=C2C=CC=C1)=CC=C2C3=NC4=CC=CC=C4C=C3
Molecular Weight: 271.31
References & Citations: [1]Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.. .
Shipping Conditions: Room Temperature
Clinical Information: No Development Reported

Cat	Name
BA4085-25	12R-LOX-IN-2
BA4085-50	12R-LOX-IN-2
BA4085-10	12R-LOX-IN-2
BA4085-100	12R-LOX-IN-2
MBS5819380	12R-LOX-IN-2
MBS5825106	12R-LOX-IN-1
MBS645657-02	ALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12)
MBS645657-01	ALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12)
BA7927-5	5-LOX-IN-2
BA7927-10	5-LOX-IN-2