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LIN28-IN-1

CAT: 0804-HY-155237Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155237Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD) . LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM) [1].
UNSPSC
12352005
Target
MicroRNA
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lin28-in-1.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=C(N2C(C(C=C([N+]([O-])=O)C(N3CCN(C(OCC4=CC=CC=C4)=O)CC3)=C5)=C5OC67CCN(CC8=CC=CC=C8)CC7)=C6C=N2)C=C1)=O
Molecular Formula
C40H38N6O7
Molecular Weight
714.77
References & Citations
[1]Borgelt L, et al. Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-Binding Protein LIN28 and Let-7. Chembiochem. 2023 Sep 1;24 (17) :e202300168.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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