SPAA-52

• Description:

  SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM) . SPAA-52 can be used in diabete research[1].

• UNSPSC:

  12352005

• Target:

  Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/spaa-52.html

• Purity:

  97.07

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S(O)(NC(NC1=CC(Br)=C(C)C(Br)=C1)=O)=O

• Molecular Formula:

  C8H8Br2N2O4S

• Molecular Weight:

  388.03

• References & Citations:

  [1]He R, et al. Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem. 2022 Oct 5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2837000-75-4]