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NWP-0476

CAT: 0804-HY-155188Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155188Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NWP-0476 is BCL-2/BCL-xL inhibitor. NWP-0476 has a modified structure with fine-tuned BCL-xL activity. NWP-0476 can be used for relapsed T-acute lymphoblastic leukemia (T-ALL) research[1].
CAS Number
[2290611-26-4]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nwp-0476.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C2=C(CN3CCN(C4=CC=C(C(NS(=O)(C5=CC=C(NC[C@H]6OCCOC6)C([N+]([O-])=O)=C5)=O)=O)C(N7CCCOC8=C7C=C9C(NC=C9)=N8)=C4)CC3)CCC(C)(C)C2)C=C1
Molecular Formula
C47H53ClN8O8S
Molecular Weight
925.49
References & Citations
[1]Saygin C, et al. Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia. Clin Cancer Res. 2023 Aug 15;29 (16) :3151-3161.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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