NWP-0476

• Description :

  NWP-0476 is BCL-2/BCL-xL inhibitor. NWP-0476 has a modified structure with fine-tuned BCL-xL activity. NWP-0476 can be used for relapsed T-acute lymphoblastic leukemia (T-ALL) research[1].

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nwp-0476.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=CC=C(C2=C(CN3CCN(C4=CC=C(C(NS(=O)(C5=CC=C(NC[C@H]6OCCOC6)C([N+]([O-])=O)=C5)=O)=O)C(N7CCCOC8=C7C=C9C(NC=C9)=N8)=C4)CC3)CCC(C)(C)C2)C=C1

• Molecular Formula :

  C47H53ClN8O8S

• Molecular Weight :

  925.49

• References & Citations :

  [1]Saygin C, et al. Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia. Clin Cancer Res. 2023 Aug 15;29 (16) :3151-3161.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2290611-26-4]