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SB-1295

CAT: 0804-HY-155065Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155065Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-1295 is an orally active CDK9/T1 inhibitor (IC50=0.17 μM) . SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer[1].
UNSPSC
12352005
Target
Apoptosis; CDK; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sb-1295.html
Solubility
10 mM in DMSO
Smiles
OC1=C2C(OC(/C=C/C3=CC=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)C[N+](C)([O-])CC4)C(O)=C1
Molecular Formula
C23H22ClNO6
Molecular Weight
443.88
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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