SB-1295

CAT: 0931-T79287-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T79287-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis|||Reactive Oxygen Species|||CDK
Related Pathways
Metabolism|||Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation|||NF-?B
Bioactivity
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 ?M, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells. It promotes cell death in MIA PaCa-2 by elevating intracellular ROS levels, diminishing mitochondrial membrane potential, and triggering apoptosis. This compound holds potential for cancer research [1].
Molecular Formula
C23H22ClNO6
Molecular Weight
443.88
Shipping Conditions
Cool pack
Storage Temperature
-20°C