SB-1295

• Target :

  Apoptosis|||Reactive Oxygen Species|||CDK

• Related Pathways :

  Metabolism|||Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation|||NF-?B

• Bioactivity :

  SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 ?M, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells. It promotes cell death in MIA PaCa-2 by elevating intracellular ROS levels, diminishing mitochondrial membrane potential, and triggering apoptosis. This compound holds potential for cancer research [1].

• Molecular Formula :

  C23H22ClNO6

• Molecular Weight :

  443.88

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C