TRAP1-IN-1

• Description :

  TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94, and disrupts TRAP1 tetramer stability, induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS, disrupts the mitochondrial membrane potential, and enhances glycolysis metabolism[1].

• CAS Number :

  [3031102-94-7]

• UNSPSC :

  12352005

• Target :

  HSP; Mitochondrial Metabolism

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/trap1-in-1.html

• Purity :

  96.03

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(O)C=CC(C(N2CC(C(F)=CC=C3)=C3C2)=O)=C1)N(C4)CC5=C4C=CC(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=C5.F[P-](F)(F)(F)(F)F

• Molecular Formula :

  C45H39F7N2O4P2

• Molecular Weight :

  866.74

• References & Citations :

  [1]Merfeld T, et al. Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur J Med Chem. 2023 Oct 5;258:115531.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported