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6-Iodoamiloride

CAT: 0804-HY-155017Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155017Size:1 Each
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Description
6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1].
CAS Number
60398-23-4
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-iodoamiloride.html
Solubility
10 mM in DMSO
Smiles
NC1=C(C(NC(N)=N)=O)N=C(I)C(N)=N1
Molecular Formula
C6H8IN7O
Molecular Weight
321.08
References & Citations
[1]Rocio K Finol-Urdaneta, et al. Automated Patch Clamp Screening of Amiloride and 5- N, N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Mol Pharm. 2023 Jul 3;20 (7) :3367-3379.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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