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DSO-5a

CAT: 0804-HY-154985Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-154985Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DSO-5a is a potent, selective, orally active BB3 agonist. DSO-5a is a representative DMAKO-00 derivative compound. DSO-5a upregulates ppar-γ activity through BB3 and activates ERK1/2 phosphorylation. DSO-5a can be used in diabetes-related research[1].
CAS Number
2195411-63-1
UNSPSC
12352005
Target
Bombesin Receptor; ERK; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dso-5a.html
Solubility
10 mM in DMSO
Smiles
C=CC(C)(C(C(C=C1OC)=C(C2=C1/C(C=C/C2=N\O)=N/O)OC)OC(C3=CC=CO3)=O)C
Molecular Formula
C23H24N2O7
Molecular Weight
440.45
References & Citations
[1]Wu L, et al. Discovery of Dimethyl Shikonin Oxime 5a, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Type 2 Diabetes Mellitus. J Med Chem. 2023 Jun 22;66 (12) :8011-8029.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ

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