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Wnt-5a

CAT: 0209-400-023Size: 25 µgDry Ice: NoHazardous: No
CAT#:0209-400-023Size:25 µg
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Description
Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to transform cells or signal through the canonical beta-catenin pathway that is so important in cancer, particularly colorectal cancer. Recent work in a wide range of human tumours has pointed to a critical role for Wnt-5a in malignant progression, but there is conflicting evidence whether Wnt-5a has a tumour-promoting or -suppressing role. Emerging evidence suggests that the functions of Wnt-5a can be drastically altered depending on the availability of key receptors. Hence, the presence or absence of these receptors may go some way to explain the conflicting role of Wnt-5a in different cancers.
Synonyms
Wnt-5a; Wnt5a; Wnt 5a; Wnt
NCBI Gene ID
7474
UniProt
P41221
Accession Number
NP_003383.2
Accession Number mRNA
NM_003392.4
Chromosomal Location
3p14-p21
Reactivity
Human
Cross Reactivity
Human
Label
His-Tag
Sequence
MIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCKLEHHHHHH
Applications
No direct biological data available at the moment but human Wnt5a binds to immobilized human sROR2 in a functional ELISA.
Assay Protocol
Human Wnt5a should be reconstituted in water to a concentration of 0.1 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Purity
> 85% by SDS-PAGE & Coomassie stain
Length
328
Form
Lyophilized
Buffer
50 mM acetic acid
Reconstitution
Water
Molecular Weight
36.9 kDa
Storage Conditions
The lyophilized human Wnt5a, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted human Wnt5a should be stored in working aliquots at -20°C.
Host or Source
E. coli
N Terminal Sequence
MIIGA

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