RSV L-protein-IN-5

RSV L-protein-IN-5

• CAS Number: 851658-28-1
• UNSPSC Description: RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection[1].
• Target Antigen: RSV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/rsv-l-protein-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(C(C)(C)C(N1CCCNCCC3=CC=C(C(OC)=C3)OC)=O)C=C(N)C4=C2NC(C5=CC=CC(C)=N5)=N4
• Molecular Weight: 556.66
• References & Citations: [1]Liuzzi M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005 Oct;79(20):13105-15.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported