RSV L-protein-IN-3

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804-HY-154966

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RSV L-protein-IN-3

CAS Number: 868860-35-9
UNSPSC Description: RSV L-protein-IN-3 is a wild-type RSV polymerase inhibitor with an IC50 value of 10.4 μM and an EC50 value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434)[1].
Target Antigen: RSV
Type: Reference compound
Related Pathways: Anti-infection
Applications: COVID-19-anti-virus
Field of Research: Infection
Assay Protocol: https://www.medchemexpress.com/rsv-l-protein-in-3.html
Solubility: 10 mM in DMSO
Smiles: O=C1C2=C3NC(C4=CC=CC=C4)=NC3=CC=C2C(C)(C)C(N1CCCNCCC5=CC=C(C(OC)=C5)OC)=O
Molecular Weight: 526.63
References & Citations: [1]Michel Liuzzi, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005, 79(20).|[2]Michael T. Rudd, et al. Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Med. Chem. Lett.. 2023，14，8. |[3]Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.|[4]Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.|[5]Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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