RSV L-protein-IN-1

RSV L-protein-IN-1

• CAS Number: 851658-10-1
• UNSPSC Description: RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC50=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection[1].
• Target Antigen: RSV
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/rsv-l-protein-in-1.html
• Purity: 98.09
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C(C(C)(C)C1=C2C3=C(NC(C4=CC=C(C)C([N+]([O-])=O)=C4)=N3)C(N)=C1)N(CCCNCCC5=CC=C(OC)C(OC)=C5)C2=O
• Molecular Weight: 600.66
• References & Citations: [1]Liuzzi M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005 Oct;79(20):13105-15.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported