TCO-GK-PEG4-NHS ester

TCO-GK-PEG4-NHS ester

• CAS Number: 2307311-19-7
• UNSPSC Description: TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2[1]. TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
• Target Antigen: ADC Linker; Radionuclide-Drug Conjugates (RDCs)
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tco-gk-peg4-nhs-ester.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)[C@H](CCCCNC(CCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)NC(CNC(OC2CC/C=C\CCC2)=O)=O
• Molecular Weight: 728.78
• References & Citations: [1]Zhou Z, et al. An Efficient Method for Labeling Single Domain Antibody Fragments with 18F Using Tetrazine- Trans-Cyclooctene Ligation and a Renal Brush Border Enzyme-Cleavable Linker. Bioconjug Chem. 2018 Dec 19;29(12):4090-4103.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported