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Tazobactam (sodium)

CAT: 0804-HY-W009168-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009168-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp..
CAS Number
89785-84-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/tazobactam-sodium.html
Purity
99.74
Solubility
DMSO : 200 mg/mL|H2O : 250 mg/mL (ultrasonic)
Smiles
C[C@]([C@@H](N1[C@@]2([H])CC1=O)C(O[Na])=O)([S]2(=O)=O)CN3C=CN=N3
Molecular Formula
C10H11N4NaO5S
Molecular Weight
322.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Giacobbe DR, et al. Ceftolozane/tazobactam: place in therapy. Expert Rev Anti Infect Ther. 2018;16 (4) :307‐320.|[2]Yang J, et al., Mechanisms of Piperacillin/Tazobactam Nephrotoxicity: Piperacillin/Tazobactam-Induced Direct Tubular Damage in Mice. Antibiotics (Basel) . 2023 Jun 28;12 (7) :1121.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β-lactam
Citation 01
Antimicrob Agents Chemother. 2024 Nov 6;68 (11) :e0077524.|Eur J Clin Microbiol Infect Dis. 2025 Mar;44 (3) :571-585.|medRxiv. 2025 Mar 13:2025.03.11.25323422.|Nat Commun. 2022 Mar 2;13 (1) :1116.|ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Antimicrob Agents Chemother. 2023 Jun 15;67 (6) :e0160322.|bioRxiv. 2024 May 10.|Eur J Clin Microbiol Infect Dis. 2025 Feb;44 (2) :277-284.|Int J Antimicrob Agents. 2025 Jun 9:107551.|Int J Med Microbiol. 2021 Oct;70 (10) .|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0303822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0069223.|Molecules. 2025 Mar 9;30 (6) :1224.|PLoS Pathog. 2024 Dec 31;20 (12) :e1012783.|Research Square Preprint. 2021 Aug.

Chemical Information

Tazobactam Sodium

Tazobactam sodium is an organic sodium salt having tazobactam(1) as the counterion; used in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections. It has a role as an antimicrobial agent, an antiinfective agent and an EC 3.5.2.6 (beta-lactamase) inhibitor. It contains a tazobactam(1-).

CAS Number89785-84-2
PubChem CID23663400
IUPAC Namesodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Molecular FormulaC10H11N4NaO5S
Molecular Weight322.28
Topological Polar Surface Area134
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity578
SMILES
C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])CN3C=CN=N3.[Na+]
InChI
InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1
InChIKey
RFMIKMMOLPNEDG-QVUDESDKSA-M
Chemical Structure
2D Structure
2D structure of Tazobactam Sodium
CAS: 89785-84-2
CID: 23663400
Formula: C10H11N4NaO5S
MW: 322.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight322.28
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass322.03478492
Monoisotopic Mass322.03478492
Topological Polar Surface Area134 Ų
Heavy Atom Count21
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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