(Rac) -Plevitrexed

• Description :

  (Rac) -Plevitrexed ((Rac) -ZD 9331; (Rac) -BGC9331) is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor. (Rac) -Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• CAS Number :

  [153538-08-0]

• Product Name Alternative :

  (Rac) -ZD 9331; (Rac) -BGC9331

• UNSPSC :

  12352005

• Target :

  Thymidylate Synthase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rac-plevitrexed.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(NC(C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2

• Molecular Formula :

  C26H25FN8O4

• Molecular Weight :

  532.53

• References & Citations :

  [1]Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[ (6S) -4,6,7,8-tetrahydro-2- (hydroxymethyl) -4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56 (13) :5446-55.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported