N2-iso-Butyroyl-2’-O-propargylguanosine

• UNSPSC Description:

  N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/n2-iso-butyroyl-2-o-propargylguanosine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@H](OCC#C)[C@H](N2C=NC3=C2N=C(NC(C(C)C)=O)NC3=O)O[C@@H]1CO

• Molecular Weight:

  391.38

• References & Citations:

  [1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2095417-55-1