N2-(Isopropylphenoxyacetyl)-2’-O-propargylguanosine

N2-(Isopropylphenoxyacetyl)-2’-O-propargylguanosine

• CAS Number: 2095417-23-3
• UNSPSC Description: N2-(Isopropylphenoxyacetyl)-2’-O-propargylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. N2-(Isopropylphenoxyacetyl)-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/n2-isopropylphenoxyacetyl-2-o-propargylguanosine.html
• Solubility: 10 mM in DMSO
• Smiles: OC[C@@H]1[C@@H](O)[C@@H](OCC#C)[C@H](N2C(NC(NC(COC3=CC=C(C(C)C)C=C3)=O)=NC4=O)=C4N=C2)O1
• Molecular Weight: 497.50
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported