5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite

5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite

• UNSPSC Description: 5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5-o-dmtr-2-2-difluoro-dc-bz-methyl-phosphonamidite.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N=C(NC(C2=CC=CC=C2)=O)C=CN1[C@H]3C(F)(F)[C@H](OP(N(C(C)C)C(C)C)C)[C@@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)O3
• Molecular Weight: 814.85
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported