5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite

5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite

• UNSPSC Description: 5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5-o-dmtr-5-medc-ac-methyl-phosphonamidite.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N=C(NC(C)=O)C(C)=CN1[C@H]2C[C@H](OP(N(C(C)C)C(C)C)C)[C@@H](COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)O2
• Molecular Weight: 730.83
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported