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GTI 2040

CAT: 0804-HY-153834Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153834Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GTI-2040, a 20-mer phosphorothioate oligonucleotide, was designed to hybridize to the mRNA sequence of human ribonucleotide reductase R2. GTI-2040 has been shown to inhibit human cancer cell proliferation by downregulation of R2 expression in vitro and to significantly inhibit tumor growth in xenograft models of human cancer in mice.
CAS Number
236391-66-5
UNSPSC
12352208
Target
DNA/RNA Synthesis
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gti-2040.html
Solubility
10 mM in H2O
Smiles
[GTI2040]
References & Citations
[1]Vassilakos A, Lee Y, Viau S, et al. GTI-2040 displays cooperative anti-tumor activity when combined with interferon alpha against human renal carcinoma xenografts. Int J Oncol. 2009;34 (1) :33-42.|[2]Ferdinandi ES, Vassilakos A, Lee Y, et al. Preclinical toxicity and toxicokinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase R2. Cancer Chemother Pharmacol. 2011;68 (1) :193-205. doi:10.1007/s00280-010-1473-z
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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