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Azido-C6-OH

CAT: 0804-HY-138521-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138521-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azido-C6-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Azido-C6-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
146292-90-2
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-c6-oh.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
OCCCCCCN=[N+]=[N-]
Molecular Formula
C6H13N3O
Molecular Weight
143.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker

Chemical Information

6-Azidohexan-1-ol
CAS Number146292-90-2
PubChem CID11051778
IUPAC Name6-azidohexan-1-ol
Molecular FormulaC6H13N3O
Molecular Weight143.19
XLogP1.9
Topological Polar Surface Area34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count10
Formal Charge0
Complexity110
SMILES
C(CCCO)CCN=[N+]=[N-]
InChI
InChI=1S/C6H13N3O/c7-9-8-5-3-1-2-4-6-10/h10H,1-6H2
InChIKey
WHYHCPIPOSTZRU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-Azidohexan-1-ol
CAS: 146292-90-2
CID: 11051778
Formula: C6H13N3O
MW: 143.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight143.19
XLogP31.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass143.105862047
Monoisotopic Mass143.105862047
Topological Polar Surface Area34.6 Ų
Heavy Atom Count10
Formal Charge0
Complexity110
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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