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Bevasiranib (sodium)

CAT: 0804-HY-153484A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153484A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bevasiranib sodium is a siRNA designed to silence the genes that produce vascular endothelial growth factor (VEGF) . It is widely accepted that vascular endothelial growth factor (VEGF) is a key component in the pathogenesis of choroidal neo-vascularization (CNV), which is a precursor to wet age-related macular degeneration (wet AMD) .
CAS Number
849758-52-7
UNSPSC
12352208
Target
Small Interfering RNA (siRNA) ; VEGFR
Type
Oligonucleotides
Related Pathways
Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bevasiranib-sodium.html
Purity
97.68
Solubility
10 mM in H2O
Smiles
[Bevasiranib(sodium)]
Molecular Formula
C401H463N153Na40O290P40
Molecular Weight
13345.2 (free acid)
References & Citations
[1]Garba AO, Mousa SA. Bevasiranib for the treatment of wet, age-related macular degeneration. Ophthalmol Eye Dis. 2010;2:75-83.|[2]Dejneka NS, Wan S, Bond OS, Kornbrust DJ, Reich SJ. Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes. Mol Vis. 2008;14:997-1005.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3

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