QR-6401

CAT: 0804-HY-153221Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-153221Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].
CAS Number
[2845096-18-4]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/qr-6401.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C1)C[C@@H]1OC2)O[C@@H](C3)CC[C@@H]3C4=CC(NC5=NC2=CC=C5)=NN4
Molecular Formula
C19H23N5O3
Molecular Weight
369.42
References & Citations
[1]Yu Y, et al. Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. ACS Med Chem Lett. 2023 Feb 8;14 (3) :297-304.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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