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QR-6401

CAT: 0931-T79014-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79014-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2845096-18-4
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/D3, and 45 nM for CDK4/D1. It exhibits potent antitumor activity in the OVCAR3 ovarian cancer xenograft model, indicating its potential for use in cancer research [1].
Smiles
O=C1OC2CC(C3=CC(NN3)=NC=4N=C(COC5CC(N1)C5)C=CC4)CC2
Molecular Formula
C19H23N5O3
Molecular Weight
369.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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