SMYD3-IN-2

• UNSPSC Description:

  SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer[1].

• Target Antigen:

  Autophagy; Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/smyd3-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]12CN(C([C@]1(O[C@@]3([C@@H]2C4=CC=C(C=C4)Br)C(NC5=CC=CC=C53)=O)O)=O)CC6=CC=CC=C6

• Molecular Weight:

  505.36

• References & Citations:

  [1]Hong-Ping Zhu, et al. Discovery of tetrahydrofuranyl spirooxindole-based SMYD3 inhibitors against gastric cancer via inducing lethal autophagy. Eur J Med Chem. 2023 Jan 15;246:115009.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported