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JB062

CAT: 0804-HY-152206Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-152206Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].
CAS Number
2417988-00-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jb062.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=C(OC)C=C3)C2=O
Molecular Formula
C19H17NO4
Molecular Weight
323.34
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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