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JB061

CAT: 0804-HY-152205-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-152205-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JB061 is a nonmuscle myosin inhibitor with IC50s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II), respectively. JB061 poorly decreases ATPase activity (IC50>200 μM) . JB061 shows cytotoxicity against COS-7 cells with an IC50 value of 39 μM[1].
UNSPSC
12352005
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jb061.html
Purity
99.27
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=CC(OC)=C3)C2=O
Molecular Formula
C19H17NO4
Molecular Weight
323.34
References & Citations
[1]Smith JD, et al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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