Mps1-IN-5

Mps1-IN-5

• CAS Number: 2890819-31-3
• UNSPSC Description: Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage[1].
• Target Antigen: Apoptosis; Mps1
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mps1-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(N5N=C(C6=CC=CC=C65)N)=N3)C=CN4
• Molecular Weight: 439.52
• References & Citations: [1]Li X, et al. Design, synthesis and biological evaluation of a new class of 7H-pyrrolo[2,3-d]pyrimidine derivatives as Mps1 inhibitors for the treatment of breast cancer. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114887.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported