ICy-Q

• Description:

  ICy-Q is a quinone oxidoreductase 1 (NQO-1) -activated near-infrared (NIR) reagent which can react with NQO-1 to release the reduction product ICy-OH. ICy-OH selectively induces pancreatic cancer cell death through the pyroptosis pathway. ICy-Q can be used as an effective tool for rapid and accurate diagnosis of intraoperative pathological sections[1].

• UNSPSC:

  12352005

• Target:

  Pyroptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/icy-q.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(C(C(C(C)(C)CC(N(C2=CC=C(C=C2)COC3=CC4=C(C=C5CCCC(/C=C/C6=[N+](C7=C(C6(C)C)C=C(C=C7)I)C)=C5O4)C=C3)C)=O)=C(C1=O)C)=O)C.[I-]

• Molecular Formula:

  C48H50I2N2O5

• Molecular Weight:

  988.73

• References & Citations:

  [1]Bo Peng, et al. NQO-1 Enzyme-Activated NIR Theranostic Agent for Pancreatic Cancer. Anal Chem. 2022 Aug 2.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2863682-83-9]